Liver weight and volume, biochemical estimations, such as measurement of transaminase activity, sgpt, scot, alkaline phosphatase, serum bilirubin, total serum proteins, albumin, globulin and prothrombin time, functional parameters, pentobarbitone. Jul 30, 2009 the activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. Jan 14, 2019 in vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Rajakumar and abdul rahuman 2011 investigated the larvicidal activity of synthesized agnps produced by aqueous extract of eclipta prostrata, a member of the asteraceae. There are no known side effects with this medicine in its regular dose. The model used was carbon tetrachloride ccl 4 induced acute hepatotoxicity in albino rats. Fengmin xi, chuntong li, junling mi, zhijun wu, wansheng chen. Alcoholic extract of eclipta alba shows in vitro antioxidant and. Hepatoprotective activity of ethanolic extract of eclipta alba in albino rats. Its effect on mitochondrial succinate dehydrogenase and adenosine 5 triphosphatase was not significant.
Pharmacological activity and chemical constituents of. Evaluation of hepatoprotective activity of amoora rohituka. Boerhaavia diffusa, eclipta alba, picrorrhiza kurroa, cichorium intybus and tinospora. Read comparative hepatoprotective activity of three phyllanthus species, p. This plant may be known by one or more common names in different places, and some are listed above. Effect of aegle marmelos and eclipta alba leaves extract on the leaves of aegle marmelos and eclipta alba. Moreover, it is very important to study the specific phytochemical compounds responsible for this hepatoprotective effect. The hepatoprotective activity of olive oil and nigella. Withania somnifera and eclipta alba ameliorate oxidative. Pdf hepatoprotective and curative effect of eclipta prostrata on. Among the two plants aegle marmelos has slightly high activity as compare to eclipta alba.
Narendra kumar paliwal tutor in pharmacology, department of pharmacology, govt. The alcoholic extract has shown antiviral activity against ranikhet disease virus. There was decreased activity of glucose6 phosphatase and fructose1,6bisphosphatase, and an increase in the activity of liver hexokinase. Mohammed ishaq 3 deccan school of pharmacy 1, hyderabad, andhra pradesh, india. Using the wellestablished animal model of concanavalin a. Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats j ananthi et al yale journal of biology and medicine 76 2003, pp. Hepatoprotective effect of enicostemma littorale blume.
Ethnopharmacological significance of eclipta alba l. There are also reports of clinical improvement in the treatment of infective hepatitis. It is a seminar on hepatoprotective drug authorstream presentation. The hepatoprotective potential of the fraction prepared from alcoholic extract was studied. A histopathological study of the liver further suggest the hepatoprotective efficacy of eclipta alba extracts fig. Collect 250 ml of eclipta alba leaves juice, 50 ml of amla juice, 50 ml of garlic juice and mix them.
Nov 10, 2019 in vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Hepatoprotective effect of eclipta alba leaves has been seen in paracetamol induced liver toxicity in rats prabu et al. Review on some medicinal plants with hepatoprotective. Massage you underfeetheel skin with eclipta alba juice regularly to cure this pain. Alcoholic extract of eclipta alba shows in vitro antioxidant. It is known in the three major forms of traditional medicinal systems in the indian subcontinent, namely, ayurveda, unani. This plant is known to have various pharmacological activities and is traditionally used in treatment but it lacks adequate scientific proof of this activity and constituents responsible for it. Evaluation of hepatorenal and haematological protection of ethanolic extract of eclipta alba in. Evaluation of hepatorenal and haematological protection of. Hepatoprotective activity extensive research corroborates the hepatoprotective activity of eclipta alba.
Unscientific use of synthetic fungicides in plant disease management has environmental ramifications, such as disease resurgence and serious health problems due to their carcinogenicity. Eclipta alba bhringraj benefits and usages ayurveda. Antibreast tumor activity of eclipta extract invitro and in. Jaya raju, investigation of hepatoprotective activity of spondias pinnata, international journal of pharma sciences and research, vol. The methanolic extract of fresh leaves of the plant eclipta alba ea was known to produce hepatoprotective activity. Methanolic extract and active principle compound of a well known indian hepatoprotective herb, eclipta alba was tested for in vitro antimicrobial studies. Comparative hepatoprotective activity of three phyllanthus. Eclipta alba definition of eclipta alba by medical. Phytochemical screening of methanolic extract and antibacterial activity of active principles of hepatoprotective herb, eclipta alba sunita dalala, sudhir k kataria b, kv sastry and svs ranac adepartment of biotechnology, kurukshetra university, kurukshetra6 119, haryana, india bdepartment of zoologybioscience, maharshi dayanand university. Indigenous drugs are being constantly explored for this purpose. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of liver and gall bladder 39. Hepatoprotective and cardiac inhibitory activities of. Dec 30, 2015 hepatoprotective effect of enicostemma littorale blume.
Ethanolic extract of eclipta alba eeea was evaluated for memory enhancing activity using. Dnadamaging steroidal alkaloids from eclipta alba from. Comparative study on hepatoprotective activity of aegle. Plants free fulltext antifungal activity of eclipta alba. The protective effect of the plant against carbon tetrachlorideinduced acute liver damage has been reported 3. Comparative study on hepatoprotective activity of aegle marmelos and eclipta alba against alcohol induced in albino rats arun. This plant may be known by one or more common names in. The effects observed were compared with a known hepatoprotective agent, silymarin. It is regarded as a weed of ethnomedicinal significance. Article received on 12012017 article revised on 03022017 article accepted on 25022017 description of eclipta alba linn. Antibreast tumor activity of eclipta extract invitro and invivo. The plant eclipta alba linn hassk family asteraceae has been mentioned in ancient texts to be a nervine tonic in addition to possessing hepatoprotective, hair growth promoting and antiaging properties.
The wide range of compounds showing antiulcer and hepatoprotective effect. The present study was designed to compare the probable hepatoprotective activity of olive oil and n. Eclipta alba extract with potential for hair growth. Kesharanjana, mochkand, bhangra plant introduction eclipta alba, the annual herbaceous plant, is also called as false daisy. Lal 1, amit kumar 1, prashant kumar 2, kuldeep singh yadav 3 1 department of pharmacy, sagar inst. Abstract eclipta alba is a herb commonly found throughout india. There are three kinds or eclipta albathe whiteflowering, the yellowflowering, and the blackfruiting, but all three grow throughout india by marshes, rivers, and. Since the liver is involved in almost all biochemical processes and there are many different diseases that will affect it. Hepatoprotective effect of wedelolactone against concanavalin. The protective effect of the plant against carbon tetrachlorideinduced acute liver dam age has been reported 3. Suresh kumar and mishra 2008 have also reported hepatoprotective effect of pergularia demia ethanol extract. Eclipta alba has been used in traditional and folklore medicine to treat. Eclipta alba extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal.
Gujerati bhangro, dadhal, kalobhangro canarase ajagara, garagadasoppu, kadiggagaraga marathi bhangra. It is whole plant of eclipta alba belonging to family compositae. The present invention provides a herbal composition comprises potent liver specific herbs which improves the liver function and also helpful in cleaning the toxic accumulations and detoxifying poisons in liver. An alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. The activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. The present study was undertaken to study the hepato protective. Sitha institute of pharmaceutical sciences 2, hyderabad, andhra pradesh, india. Ea significantly counteracted ccl 4induced inhibition of the hepatic microsomal drug metabolising enzyme amidopyrine ndemethylase and membrane bound glucose 6phosphatase, but failed to reverse the very high degree of. Andrographis paniculata, eclipta alba, picrorrhiza kurroa, silibum marianum, phyllanthus and trichopus zeylanicus, etc. Oct 29, 2014 an alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62.
Bhringraj is a widely celebrated medicinal plant, especially in india, used singly or in combination with other herbs such as amala, shikaakai for making a vast range of hair care, hair rinse and conditioner products. The wide range of compounds showing antiulcer and hepatoprotective effect, among them flavonoids is most important. Eightyone wistar albino rats were divided into four groups. Screening of leaves and roots of eclipta alba for hepatoprotective activity v. This wonderful plant may be found as an erect or prostrate with many branches having roughly hair. These herbal drugs have equivalent therapeutic value with the standards drug silymarin. Mode of antibacterial activity of eclalbasaponin isolated from eclipta alba. The herbal composition of present invention comprises extract of andrographis paniculata.
The current study aimed to investigate the hepatoprotective effect of wedelolactone, a major coumarin ingredient of eclipta prostrata l. Wo2011074001a2 a hepatoprotective herbal composition. Evaluation of hepatorenal and haematological protection. Eclipta alba extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal pathogens fusarium thapsinum, alternaria alternata, epicoccum sorghinum, and curvularia lunata. Hepatoprotective activity of eclipta alba is well described in literature 33, 3538. Global journal of medical research 36 volume xiii issue vii version i year. Hepatoprotective activity of ethanolic extract of eclipta. Hepatoprotective activity of eclipta alba pdf indian j physiol pharmacol. Eclipta alba false daisy is a herb that has traditionally been used in ayurvedic medicine for being a liver tonic for which it is one of the more effective herbs apparently and having beneficial effects on diabetes, eye health, and hair growth in regards to these claims, it appears to have some antidiabetic effects in animal studies with the mechanism of action not yet known. Hepatoprotective role of eclipta alba against high fatty diet. Visited 467 times, 1 visits today downloads pdf downloads.
The present study deals with hepatoprotective activity observed with ethanolic extracts of plant leaves and leaf callus of eclipta alba l. Since the time of ayurveda till today bhringraj eclipta alba is a topnotch herb used in hair care industry. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr. Hepatoprotective effects of eclipta alba on subcellular. Eclipta alba extract with potential for hair growth promoting. The previous studies shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes saxena ak, et al. The study was designed to evaluate the hepatoprotective activity of p. Mar 21, 2017 since the time of ayurveda till today bhringraj eclipta alba is a topnotch herb used in hair care industry. The fresh plant is used as self medication by aids. These findings suggest that methanol extract of eclipta alba may have potential as a hair growth promoter. Hepatoprotective activity of ethanolic extract of eclipta alba in. Aerial parts of eclipta alba are used traditionally for the treatment of several diseases of liver, skin and stomach. Applied biochemistry and biotechnology 20, 171, 20032019. Hepatoprotective effects of eclipta alba on subcellular levels in rats.
Jun 20, 2018 eclipta alba false daisy is a herb that has traditional usage as a liver tonic in ayurveda. The heptoprotective of the study confirmed the hepatoprotective activity of aqueous extracts of e. The effect of agnps was studied against fourth instar larvae of filariasis vector, culex quinquefasciatus and malaria vector anopheles subpictus grass rajakumar and abdul. Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats. This has prompted the identification and development of ecofriendly greener alternatives. Some study showed that hepatoprotective activity of the extract of e. There are three kinds or eclipta alba the whiteflowering, the yellowflowering, and the blackfruiting, but all three grow throughout india by marshes, rivers, and lakes or on the foothills of the himalayas. U 405 international journal of environmental sciences volume 2 no. Tabassum n, agrawal ss 2004 hepatoprotective activity of eclipta alba hassk. The maintenance of a healthy liver is vital to overall health of the human beings. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of. Pharmacological activity and chemical constituents of ecliptaalba.
In indian systems of medicines herbal decoction of eclipta alba. The objective of the present study was to evaluate the effect of eclipta alba l. The observations of these dose, clearly indicat the involvement of heptoprotective active principles in eclipta alba. Eclipta alba is being examined for its memory enhancing quality as it is traditionally used for this purpose. It appears to have preliminary evidence to suggest hair growth promotion as potent as minoxidil and some antidiabetic effects as well as liver protection.
It is used in medicines of pediatric conditions and in lactating mothers. Hindi balari, bhangra, bhringraj, bhengra, mochkand, bhangaraiya. It is a weed which grows in tropical and subtropical regions all over the world. Collect 250 ml of eclipta alba leaves juice, 50 ml. Eclipta alba supplement health benefits, dosage, side. Agrawal, hepatoprotective activity of emebelia ribes against paracetamol induced acute hepatocellular damage in mice, experimental medicine, 2003, vol. Hepato protective activity of eclipta alba liver protective action phytochemical standardization hair growth promotion activity. Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. Antibreast tumor activity of eclipta extract invitro and. The study shows that hepatoprotective activity of ea is. Wagner h, geyer b, kiso y, hikino h, rao gs 1986 coumestans as the main active principles of the liver drugs eclipta alba and wedella calendulaceae. The most commonly used parameters to assess the hepatoprotective activity are morphological e. The liver is often abused by environmental toxins, which are eating habits, alcohol and overdose of certain drugs which can damage and weaken the liver and eventually lead to many diseases.
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